KU-0060648
Data Sheet
For research use only. Not for human use.
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| CAS No. | 881375-00-4 | Cat. No. | BCP09056 |
| Name | KU-0060648 | ||
| Synonyms | KU0060648; KU 0060648; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C33H34N4O4S | M. Wt | 582.71 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K (IC50 = 19 nM for DNA-PK autophosphorylation in MCF7 cells). Inhibits proliferation of MCF7 cells and delays growth of MCF7 xenografts. Also thought to inhibit PI 3-K in a cell line-dependent manner (IC50 values are <0.1, 0.5 and 4 nM for PI 3-Kδ, PI 3-Kβ and PI 3-Kα in a cell-free assay). | ||
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