Razuprotafib New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1008510-37-9 | Cat. No. | BCP46999 |
| Related Products | 1809275-69-1（Razuprotafib sodium） | ||
| Name | Razuprotafib | ||
| Synonyms | AKB-9778; AKB 9778; AKB9778; | ||
| SMILES | COC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4 | ||
| Chemical Name | |||
| Formula | C26H26N4O6S3 | M. Wt | 586.7 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Razuprotafib is a small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), with potential vasculature stabilizing activity. Upon administration, razuprotafib targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation, which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated in stressed endothelium associated with a variety of diseases. Tie2 plays an important role in endothelial function and vascular stability. A decrease in Tie2 activation leads to vascular leakage and inflammation. | ||
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