Raphin1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2022961-17-5 | Cat. No. | BCP48938 |
| Related Products | 2242616-04-0（Raphin1 acetate） | ||
| Name | Raphin1 | ||
| Synonyms | Raphin 1;Raphin-1; | ||
| SMILES | C1=CC(=C(C(=C1)Cl)Cl)C=NN=C(N)N | ||
| Chemical Name | |||
| Formula | C8H8Cl2N4 | M. Wt | 231.08 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease. | ||
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