CZC-54252

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15148CAS No. ：1191911-27-9Purity：98%

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CAS No.	1191911-27-9	Cat. No.	BCP15148
Related Products	1784253-05-9（CZC 54252 hydrochloride）
Name	CZC-54252
Synonyms	CZC54252;CZC 54252;
SMILES	CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O
Chemical Name
Formula	C22H25ClN6O4S	M. Wt	504.99
Purity	98%	Storage	Store at 4-8°C
Description	CZC-54252 inhibited the activity of recombinant human wild-type LRRK2 with an IC50 ranging from ～1 to ～5 nM. The G2019S mutant was inhibited with an IC50 ranging from ～2 to ～7 nM in a TF-FRET assay. In addition, they were screened against a kinase panel of 185 kinases and exhibited good selectivity. CZC-25146 (19) inhibited five other kinases, PLK4, GAK, TNK1, CAMKK2, and PIP4K2C, with high potency only, but none of them have been classified as predictors of genotoxicity or hematopoietic toxicity [1]. G2019S LRRK2-induced human neuronal injury was attenuated by CZC-25146 with an EC50 of ~4 nM (EC50 CZC-54252 ~1 nM) and fully reversed to wild-type levels by both compounds at concentrations as low as 8 nM (1.6 nM for CZC-54252) . in vivo: In vivo pharmacology established a volume of distribution of 5.4 L/kg and a clearance of 2.3 L/h/kg for CZC-25146.