LRRK2-IN-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1234480-84-2 | Cat. No. | BCP14860 |
| Name | LRRK2-IN-1 | ||
| Synonyms | LRRK2-IN 1; LRRK2-IN1; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H38N8O3 | M. Wt | 570.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. LRRK2-IN-1 demonstrates potent anti-cancer activity including inhibition of cancer cell proliferation, migration, and invasion as well as induction of apoptosis and cell cycle arrest. LRRK2-IN-1 suppresses DCLK1 kinase activity and downstream DCLK1 effector c-MYC, and demonstrate that DCLK1 kinase activity is a significant factor in resistance to LRRK2-IN-1. | ||
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