CZC 54252 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1784253-05-9 | Cat. No. | BCP47285 |
| Related Products | 1191911-27-9（CZC-54252） | ||
| Name | CZC 54252 hydrochloride | ||
| Synonyms | CZC-54252 HCl;CZC54252 HCl;CZC 54252 HCl; | ||
| SMILES | COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl | ||
| Chemical Name | |||
| Formula | C22H26Cl2N6O4S | M. Wt | 541.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. | ||
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