Sardomozide dihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 138794-73-7 | Cat. No. | BCP29424 |
| Name | Sardomozide dihydrochloride | ||
| Synonyms | CGP 48664A;CGP-48664A;CGP48664A; | ||
| SMILES | NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.[H]Cl.[H]Cl | ||
| Chemical Name | |||
| Formula | C11H16Cl2N6 | M. Wt | 303.19 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sardomozide dihydrochloride, also known as CGP48664A, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. | ||
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