NKP-1339

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP26252CAS No. ：197723-00-5Purity：98%

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CAS No.	197723-00-5	Cat. No.	BCP26252
Name	NKP-1339
Synonyms	NKP 1339;NKP1339;KP1339;KP 1339;KP-1339;
SMILES	[Cl-][Ru+3]([N]1=CC2=CC=CC=C2N1)([Cl-])([Cl-])([N]3=CC4=CC=CC=C4N3)[Cl-].[Na+]
Chemical Name
Formula	C14H12Cl4N4NaRu	M. Wt	502.14
Purity	98%	Storage	Store at 4-8°C
Description	NKP-1339, also known as KP-1339, is a ruthenium-containing cancer agent targeting transferrin with potential antineoplastic activity. Upon intravenous administration, NKP-1339 (Ru3+) binds to transferrin (Tf) and is taken up via Tf receptors (TfR), which are overexpressed on cancer cells. Once inside the cell, NKP-1339 is released from Tf and is reduced, within the acidic environment of the endosomes, to its active form NKP-119 (Ru2+). In turn, the active form induces a redox reaction, thereby leading to the formation of reactive oxygen species (ROS) which inhibits GRP78 and SOD, endoplasmic reticulum-stress modulating molecules as well as BAG4 and ERK, program cell death regulating molecules.This eventually induces caspase-dependent apoptosis.