Home   >  
Ion Channel/Membrane Transporter
  >  
Potassium Channel
  >   Retigabine Dihydrochloride
Retigabine Dihydrochloride Chemical Structure

Retigabine Dihydrochloride

Cat. No. :BCP07747CAS No. :150812-13-8Purity:98%
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • Information
  • Introduction
  • Quality Control
Synonyms Retigabine 2HCl;D20443 dihydrochloride;D 20443 dihydrochloride;Ezogabine Dihydrochloride
CAS Number 150812-13-8
Purity 98%
M. Wt 376.25
Formula C16H20Cl2FN3O2
Storage Store at 4-8°C
Retigabine is a novel antiepileptic compound with broad spectrum and potent anticonvulsant properties, both in vitro and in vivo. The compound was shown to activate a K+ current in neuronal cells. The pharmacology of the induced current displays concordance with the published pharmacology of the M-channel, which recently was correlated to the KCNQ2/3 K+ channel heteromultimere. Retigabine is a novel anticonvulsant with an unknown mechanism of action. Application of 10 μM retigabine to oocytes expressing the KCNQ2/3 heteromeric channel shifted both the activation threshold and voltage for half-activation by approximately 20 mV in the hyperpolarizing direction, leading to an increase in current amplitude at test potentials between ?80 mV and +20 mV. Retigabine also had a marked effect on KCNQ current kinetics, increasing the rate of channel activation but slowing deactivation at a given test potential. Retigabine shifted the voltage dependence of channel activation with an EC50

Tags:Retigabine Dihydrochloride supplier,Retigabine Dihydrochloride purchase,Retigabine Dihydrochloride manufacturer,Retigabine Dihydrochloride distributor,Retigabine Dihydrochloride cost,Retigabine Dihydrochloride buy,Retigabine Dihydrochloride for sale

0086-15971444841