FTI-277 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 170006-73-2 | Cat. No. | BCP32847 |
| Name | FTI-277 | ||
| Synonyms | FTI 277; FTI277; | ||
| SMILES | COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2 | ||
| Chemical Name | |||
| Formula | C22H29N3O3S2 | M. Wt | 447.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | FTI-277 is a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. | ||
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