Tipifarnib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02262CAS No. ：192185-72-1Purity：98%

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CAS No.	192185-72-1	Cat. No.	BCP02262
Name	Tipifarnib
Synonyms	Zarnestra;IND 58359;R115777;IND-58359;IND58359;R-115777;R 115777;
SMILES
Chemical Name
Formula	C27H22Cl2N4O	M. Wt	489.4
Purity	98%	Storage	Store at 4-8°C
Description	Using Tipifarnib 5 μM for 72 hours, the percentage of apoptotic cells is significantly higher in drug-treated compared to DMSO-treated LGL T-cells. Using T-cells from healthy donors, Tipifarnib reduces the percentage of IFNγ-positive cells in a time-dependent manner. Tipifarnib reduces the amount of activated Ras in precipitates compared to DMSO.Tipifarnib exerts selective in vitro toxicity against clonal MDS hematopoiesis at concentrations less than 10 nM the effect being more prominent in white cell progenitors. This action is not due to apoptosis induction as both normal and MDS progenitors displays equivalent DiOC3 and annexin V expression up to 72 hours after exposure to Tipifarnib.Combining Tipifarnib with 10 nM 4-OH-tamoxifen in the presence of E2 reduces the IC50 8-fold from 400 to 50 nM.Tipifarnib induces apoptosis in U937 cells. [5] In addition, Tipifarnib inhibits isolated human farnesyltransferase for a lamin B peptide and for the K-RasB peptide with IC50 of 0.86 nM and 7.9