L-778123 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 183499-57-2 | Cat. No. | BCP44918 |
| Name | L-778123 | ||
| Synonyms | L 778123; L778123; L-778,123; L 778,123; L778,123; | ||
| SMILES | C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl | ||
| Chemical Name | |||
| Formula | C22H20ClN5O | M. Wt | 405.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. | ||
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