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Repotrectinib Chemical Structure

Repotrectinib

Cat. No. :BCP19778CAS No. :1802220-02-5Purity:98%
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Synonyms TPX-0005;TPX 0005; TPX0005
CAS Number 1802220-02-5
Purity 98%
M. Wt 355.37
Formula C18H18FN5O2
Storage Store at 4-8°C
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.TPX-0005 is a Src/FAK/Janus kinase 2 (JAK2) inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.

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