BAY-598 R-isomer New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1906920-28-2 | Cat. No. | BCP44956 |
| Name | BAY-598 R-isomer | ||
| Synonyms | BAY 598 R-isomer; BAY598 R-isomer; | ||
| SMILES | CCN(C1CN(N=C1C2=CC(=C(C=C2)Cl)Cl)C(=NC3=CC(=CC=C3)OC(F)F)NC#N)C(=O)CO | ||
| Chemical Name | |||
| Formula | C22H20Cl2F2N6O3 | M. Wt | 525.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 µM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar. | ||
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