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UNC6934 Chemical Structure

UNC6934

Data Sheet For research use only. Not for human use.
Cat. No. :BCP45445CAS No. :2561494-77-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2561494-77-5 Cat. No. BCP45445
Name UNC6934
Synonyms UNC6934;UNC-6934;
SMILES C1CC1N(CC2=CC=C(C=C2)C(=O)NC3=NC=NC=C3)C(=O)C4=CC5=C(C=C4)NC(=O)CO5
Chemical Name
Formula C24H21N5O4 M. Wt 443.46
Purity 98% Storage Store at 4-8°C
Description UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.
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