MRTX1719 New
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 10.00 mg | Get quote | In-stock | Quotation Inquiry |
| 20.00 mg | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 2630904-45-7 | Cat. No. | BCP44551 |
| Related Products | MRTX1719HCl（MRTX-1719 HCl） | ||
| Name | MRTX1719 | ||
| Synonyms | MRTX-1719;MRTX 1719; | ||
| SMILES | O=C1C2=CC=C(C3=[C@]([C@]4=C(C#N)C(OC5CC5)=CC(Cl)=C4F)N(C)N=C3)C=C2C(CN)=NN1 | ||
| Chemical Name | |||
| Formula | C23H18ClFN6O2 | M. Wt | 464.89 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MRTX1719 is a potent and selective binder to the PRMT5•MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells. Daily oral administration of MRTX1719 to tumor xenograft-bearing mice demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity. | ||
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