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PF-04802367 Chemical Structure

PF-04802367

Data Sheet For research use only. Not for human use.
Cat. No. :BCP44964CAS No. :1962178-27-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1962178-27-3 Cat. No. BCP44964
Name PF-04802367
Synonyms PF04802367;PF 04802367;PF367;PF 367;PF-367;
SMILES COC1=C(C=C(C=C1)C2=C(N=CO2)C(=O)NCCCN3C=NC=N3)Cl
Chemical Name
Formula C16H16ClN5O3 M. Wt 361.78
Purity 98% Storage Store at 4-8°C
Description PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 shows desirable central nervous system (CNS) properties and potency. PF-04802367 is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively[1].
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