Tebanicline HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 203564-54-9 | Cat. No. | BCP25177 |
| Related Products | 198283-74-8（Tebanicline tosylate） 209326-18-1（Tebanicline dihydrochloride） 209326-18-1（Tebanicline benzoate） 198283-73-7（Tebanicline） | ||
| Name | Tebanicline HCl | ||
| Synonyms | Tebanicline hydrochloride;ABT594 HCl;Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C9H12Cl2N2O | M. Wt | 235.11 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.Tebanicline, also known as ABT-594 and Ebanicline, a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. | ||
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