PD 166285 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 212391-63-4 | Cat. No. | BCP22349 |
| Name | PD 166285 dihydrochloride | ||
| Synonyms | PD-166285 dihydrochloride;PD-166285 2HCl;PD166285 dihydrochloride; | ||
| SMILES | CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H29Cl4N5O2 | M. Wt | 585.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. | ||
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