A-770041 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 869748-10-7 | Cat. No. | BCP30674 |
| Name | A-770041 | ||
| Synonyms | A 770041; A770041; | ||
| SMILES | CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)C(=NC=N4)N | ||
| Chemical Name | |||
| Formula | C34H39N9O3 | M. Wt | 621.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-770041 is a potent ans selective LCK inhibitor. Concanavalin A-stimulated IL-2 production in whole blood is inhibited by A-770041 with an EC50 of approximately 80 nM. A-770041 is orally bioavailable (F = 34.1 +/- 7.2% at 10 mg/kg) and has a t(1/2) of 4.1 +/- 0.1 h. Concanavalin A-induced IL-2 production in vivo is inhibited by oral administration of A-770041 (in vivo EC50 = 78 +/- 28 nM). A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. A-770041 prevents organ allograft rejection. | ||
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