Elzovantinib New
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| CAS No. | 2271119-26-5 | Cat. No. | BCP40929 |
| Name | Elzovantinib | ||
| Synonyms | TPX-0022; TPX 0022; TPX0022;CSF1R-IN-2; | ||
| SMILES | CCN1CC2=C(C=CC(=C2C#N)F)OC(CNC(=O)C3=C4N=C1C=CN4N=C3N)C | ||
| Chemical Name | |||
| Formula | C20H20FN7O2 | M. Wt | 409.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TPX-0022, also known as CSF1R-IN-2, is an orally bioavailable multi-targeted kinase inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases. Targeting CSF1R leads to the modulation of tumor-associated macrophages (TAMs), a type of immune cell that suppresses the T-cell mediated anti-tumor immune response. Inhibition of CSF1R with TPX-0022 is a promising therapeutic strategy as a single agent or in combination with standard of care chemotherapy and immunotherapy in various solid tumors. | ||
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