MRTX849 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31538CAS No. ：2326521-71-3Purity：98%

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CAS No.	2326521-71-3	Cat. No.	BCP31538
Related Products	2490716-96-4（MRTX849 analog 24） 2561529-96-0（MRTX849 acid）
Name	MRTX849
Synonyms	MRTX-849; MRTX 849;
SMILES	N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1
Chemical Name
Formula	C32H35ClFN7O2	M. Wt	604.13
Purity	98%	Storage	Store at 4-8°C
Description	MRTX849 is a potent, highly selective, oral available KRAS G12C inhibitor. MRTX849 maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. MRTX849 exhibited significantly improved half-life and penetration into the tumor, shutting down KRAS signaling for the entire dosing interval, and showing a higher degree of antitumor activity than previous KRAS mutant-selective inhibitors.