PXS5505 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP39658CAS No. ：2409963-83-1Purity：98%

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CAS No.	2409963-83-1	Cat. No.	BCP39658
Name	PXS5505
Synonyms	PXS-5505;PXS 5505;LOX-IN-3;LOXIN3,LOX IN 3;
SMILES	C1=CC2=C(C(=C1)S(=O)(=O)CC(=CCN)F)N=CC=C2
Chemical Name
Formula	C13H13FN2O2S	M. Wt	280.32
Purity	98%	Storage	Store at 4-8°C
Description	Pan-LOX Inhibitor PXS-5505 is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (LOX) family members, with potential antifibrotic activity. Upon oral administration, pan-LOX inhibitor PXS-5505 targets, binds to and inhibits the activity of all enzymes in the LOX family. This prevents the post-translational oxidative deamination of lysine residues on target proteins, including collagen and elastin, and reduces the formation of deaminated lysine (allysine), the formation of inter- and intramolecular cross-linkages and may prevent remodeling of the extracellular matrix (ECM), thereby reducing fibrotic tissue formation in certain chronic fibrotic diseases. LOX is often upregulated in fibrotic tissue and plays a key role in fibrosis.