GGTI-2418 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP30523CAS No. ：501010-06-6Purity：98%

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CAS No.	501010-06-6	Cat. No.	BCP30523
Name	GGTI-2418
Synonyms	GGTI2418; GGTI 2418; PTX-100; PTX 100; PTX100;Geranylgeranyl transferase inhibitor-2148;
SMILES	CC1=C(N=CN1)CN2CCN(C(C2=O)CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)O
Chemical Name
Formula	C23H31N5O4	M. Wt	441.53
Purity	98%	Storage	Store at 4-8°C
Description	GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt.