R-268712 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 879487-87-3 | Cat. No. | BCP25191 |
| Name | R-268712 | ||
| Synonyms | R 268712; R268712; | ||
| SMILES | CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC(=C(C=C3)F)C4=CN(N=C4)CCO | ||
| Chemical Name | |||
| Formula | C20H18FN5O | M. Wt | 363.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer. | ||
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