LDC1267
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1361030-48-9 | Cat. No. | BCP14023 |
| Name | LDC1267 | ||
| Synonyms | LDC-1267;LDC 1267; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C30H26F2N4O5 | M. Wt | 560.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: LDC1267 preferentially inhibits Tyro3,Axl andMer at lownanomolarity, as determined by tracer-based binding assays. Treatment of NKG2D activated NK cells with LDC1267 indeed abolished the inhibitory effects of Gas6 stimulation;LDC1267 had no apparent additional effect in Cbl-b-deficient NK cells. in vivo: wild-type mice treated with LDC1267 showed enhanced cytotoxicity towardsRMAcells overexpressing the NKG2D ligand Rae-1 (RMA-Rae1) to the same extent as C373AKI/KI mice, but had no effect on the already enhanced NK cytotoxicity in Cbl-b-mutant mice. Challenged mice with B16F10 melanoma followed by intraperitoneal LDC1267 treatment. LDC1267 markedly reduced metastatic spreading ofmelanomas; NK1.1 depletion abolished the therapeutic benefits of LDC1267. | ||
Recommend Products
More >
-
Batiraxcept
Cat. No.：BCP49357
No.：2268717-61-7
Product Details -
Ningetinib
Cat. No.：BCP46143
No.：1394820-69-9
Product Details -
Gilteritinib hemifumarate
Cat. No.：BCP40569
No.：1254053-84-3
Product Details -
-
-
-
-
-
S49076 HCl
Cat. No.：BCP29576
No.：1265966-31-1
Product Details -
Sitravatinib
Cat. No.：BCP29099
No.：1123837-84-2
Product Details -
BMS 777607
Cat. No.：BCP13190
No.：1196681-44-3
Product Details -
Glesatinib hydrochloride
Cat. No.：BCP18872
No.：1123838-51-6
Product Details -
-
-
-
-
-
-
-
Tags:LDC1267 supplier,LDC1267 purchase,LDC1267 manufacturer,LDC1267 distributor,LDC1267 cost,LDC1267 buy,LDC1267 for sale