UNC2250 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1493694-70-4 | Cat. No. | BCP09929 |
| Name | UNC2250 | ||
| Synonyms | UNC-2250;UNC 2250; | ||
| SMILES | O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1 | ||
| Chemical Name | |||
| Formula | C24H36N6O2 | M. Wt | 440.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional antitumor activity. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. | ||
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