RN983 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP44110CAS No. ：1423129-83-2Purity：98%

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CAS No.	1423129-83-2	Cat. No.	BCP44110
Name	RN983
Synonyms	RN-983; RN 983;
SMILES	CC(C)(C)C1=CC2=C(C(=C1)F)C(=O)N(N=C2)C3=NC=CC(=C3CO)C4=NN(C(=O)C(=C4)NC5=NC=C(C=C5)C6CCN(CC6)C)C
Chemical Name
Formula	C34H37FN8O3	M. Wt	624.71
Purity	98%	Storage	Store at 4-8°C
Description	RN983 is a potent and selective BTK inhibitor. RN983 potently, selectively, and reversibly inhibited the Btk enzyme. RN983 displayed functional activities in human cell-based assays in multiple cell types, inhibiting IgG production in B-cells with an IC50 of 2.5 ± 0.7 nM and PGD2 production from mast cells with an IC50 of 8.3 ± 1.1 nM. RN983 displayed similar functional activities in the allergic mouse model of asthma when delivered as a dry powder aerosol by nose-only inhalation. Inhalation of aerosolized RN983 may be effective as a stand-alone asthma therapy or used in combination with inhaled steroids and β-agonists in severe asthmatics due to its potent inhibition of mast cell activation.