Olmutinib dihydrochloride New
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For research use only. Not for human use.
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| CAS No. | 1842366-97-5 | Cat. No. | BCP38296 |
| Name | Olmutinib dihydrochloride | ||
| Synonyms | BI-1482694 CL2; BI1482694 CL2; BI 1482694 CL2; | ||
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H28Cl2N6O2S | M. Wt | 559.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both promote cell survival and proliferation. | ||
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