Home   >  
Angiogenesis/Protein Tyrosine Kinase
  >  
BTK
  >   BMS-986195
BMS-986195 Chemical Structure

BMS-986195

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP29496CAS No. ：1912445-55-6Purity：98%
chem_1Get Quotation Now
 Tel: 0086-13026320035   or   orders@biochempartner.com
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
  • Chemical Properties&Biological Activity
CAS No. 1912445-55-6 Cat. No. BCP29496
Name BMS-986195
Synonyms BMS986195; BMS986195;
SMILES FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
Chemical Name
Formula C20H23FN4O2 M. Wt 370.43
Purity 98% Storage Store at 4-8°C
Description BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a member of the Tec family of non-receptor tyrosine kinases essential in antigen-dependent B-cell signaling and function. BMS-986195 is more than 5000-fold selective for BTK over all kinases outside of the Tec family, and selectivity ranges from 9- to 1010-fold within the Tec family. BMS-986195 inactivated BTK in human whole blood with a rapid rate of inactivation (3.5×10-4 nM-1·min-1) and potently inhibited antigen-dependent interleukin-6 production, CD86 expression and proliferation in B cells (IC50 <1 nM) without effect on antigen-independent measures in the same cells.
  • Quality Control&Technical Support
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.

Recommend Products

More >

Tags:BMS-986195 supplier,BMS-986195 purchase,BMS-986195 manufacturer,BMS-986195 distributor,BMS-986195 cost,BMS-986195 buy,BMS-986195 for sale

0086-13720134139