Home   >  
Cell Cycle/DNA Damage
  >  
DUB
  >   SJB2-043
SJB2-043 Chemical Structure

SJB2-043

Cat. No. :BCP11060CAS No. :63388-44-3Purity:98%
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • Information
  • Introduction
  • Quality Control
Synonyms SJB2 043;SJB2043
CAS Number 63388-44-3
Purity 98%
M. Wt 275.26
Formula C17H9NO3
Storage Store at 4-8°C
Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed by immunoblotting with anti-USP1 or anti-HA antibodies. Consistent with our previous studies and the most recent studies by Piatkov et al (24, 31, 33), USP1 in the untreated cells was detected on western blot as a doublet; full length USP1 and an auto-cleaved USP1 with only N-terminus. The Ub-USP1 conjugates were generated in the untreated cell lysates and were detected by an increase in molecular weight of USP1. However, the formation of the Ub-USP1 conjugate was inhibited by the addition of SJB2-043. Ub-aldehyde, a potent known nonspecific DUB inhibitor, caused a complete loss of USP1-Ub-VS conjugates in this competition assay. SJB2-043 inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes. In addition, SJB2-043 inhibited the labeling of USP1 with Ub-VS in a dose dependent manner.

Tags:SJB2-043 supplier,SJB2-043 purchase,SJB2-043 manufacturer,SJB2-043 distributor,SJB2-043 cost,SJB2-043 buy,SJB2-043 for sale

0086-15971444841