A 83-01

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05991CAS No. ：909910-43-6Purity：98%

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CAS No.	909910-43-6	Cat. No.	BCP05991
Name	A 83-01
Synonyms	A83-01; A-83-01;
SMILES
Chemical Name
Formula	C25H19N5S	M. Wt	421.52
Purity	98%	Storage	Store at 4-8°C
Description	A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity and is more potent than SB 431542. in vitro: A-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation . Microarray analysis of HM-1 cells treated with TGF-β1 and/or A-83-01 revealed that A-83-01 efficiently inhibited transcriptional changes that are induced by TGF-β1. -83-01 treatment significantly increased these parameters within 24 h that was positively related to pericyte coverage and tumor cell proliferation. Furthermore, apparent diffusion coefficient (ADC) determined by diffusion-weighed imaging was decreased by A-83-01 treatment, suggesting the decrease of tumor interstitial fluid pressure. Vascular function of the tumor improved by A-83-01treatment well assessed on post-Gd-L-enhanced MR images . in vivo: The targeting efficacy of single intraveno