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HBX 41108 Chemical Structure

HBX 41108

Cat. No. :BCP08394CAS No. :924296-39-9Purity:98%
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Synonyms HBX41108; HBX-41108; HBX 41,108; HBX-41,108; HBX41,108
CAS Number 924296-39-9
Purity 98%
M. Wt 266.64
Formula C13H3ClN4O
Storage Store at 4-8°C
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.

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