Raltitrexed New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02874CAS No. ：112887-68-0Purity：98%

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CAS No.	112887-68-0	Cat. No.	BCP02874
Name	Raltitrexed
Synonyms	TDX;ZD 1694;ZD1694;ZD-1694;Tomudex;D1694; ICID1694; D-1694; ICID-1694; D 1694; ICID 1694;;
SMILES
Chemical Name
Formula	C21H22N4O6S	M. Wt	458.49
Purity	98%	Storage	Store at 4-8°C
Description	Raltitrexed (Tomudex) is an antimetabolite drug used in cancer chemotherapy. Raltitrexed (Tomudex) is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting Dihydrofolate reductase, an enzyme used in the synthesis of tetrahydrofolate, thereby preventing the synthesis of thymidylate.In a study, there was an inverse relationship between reduced folate cellular content and raltitrexed IC50; this relationship did not, however, reach statistical significance. The only significant relationship was found between basal cellular folylpolyglutamate synthetase activity and raltitrexed IC50r = -0.56, p = 0.03. Tumor cells with a relatively high folylpolyglutamate synthetase activity were more sensitive to raltitrexed cytotoxic effects and vice versa.