Doxifluridine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 3094-09-5 | Cat. No. | BCP12582 |
| Name | Doxifluridine | ||
| Synonyms | Flutron;Furtulon;Ro 21-9738;5-Fluoro-5(acute)-deoxyuridine; 5(acute)-DFUR; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C9H11FN2O5 | M. Wt | 246.19 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand. in vitro: 5'-DFUR's metabolic product(N3-Me-5'-dFUR) was found to be non-toxic in all the cell growth experiments performed. The absence of cytotoxicity could be explained by the observation that the metabolite was not recognized as a substrate by thymidine phosphorilase, the enzyme responsible for 5-fluorouracil (5-FU) release from doxifluridine, as ascertained by high-performance liquid chromatography/ultraviolet (HPLC-UV) analysis of t | ||
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