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RX3117 Chemical Structure

RX3117

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP10720CAS No. ：865838-26-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 865838-26-2 Cat. No. BCP10720
Name RX3117
Synonyms RX-3117;RX 3117; TV1360; TV1360; TV 1360; Fluorocyclopentenylcytosine;
SMILES
Chemical Name
Formula C10H12FN3O4 M. Wt 257.22
Purity 98% Storage Store at 4-8°C
Description RX-3117, also known as TV-1360, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1).
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