AGI-5198
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1355326-35-0 | Cat. No. | BCP07382 |
| Name | AGI-5198 | ||
| Synonyms | IDH-C35; AGI5198; AGI 5198; IDH C35; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H31FN4O2 | M. Wt | 462.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AGI-5198, a novel R132H-IDH1 inhibitor, identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG). The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. Isocitrate dehydrogenase 1 (IDH1) is one potential drug target, which is mutated in multiple human cancers. | ||
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