Vorasidenib New
Data Sheet
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| CAS No. | 1644545-52-7 | Cat. No. | BCP20782 |
| Name | Vorasidenib | ||
| Synonyms | AG-881;AG 881; AG881; | ||
| SMILES | CC(C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)NC(C)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C14H13ClF6N6 | M. Wt | 414.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations. | ||
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