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Enasidenib Chemical Structure

Enasidenib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16041CAS No. :1446502-11-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1446502-11-9 Cat. No. BCP16041
Name Enasidenib
Synonyms AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007;
SMILES CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1
Chemical Name
Formula C19H17F6N7O M. Wt 473.37
Purity 98% Storage Store at 4-8°C
Description Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.
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