Ivosidenib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1448347-49-6 | Cat. No. | BCP15362 |
| Name | Ivosidenib | ||
| Synonyms | AG-120; AG 120; AG120; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H22ClF3N6O3 | M. Wt | 582.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. | ||
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