Home   >  
Protease/Metabolic Enzyme
  >  
IDH
  >   BAY-1436032
BAY-1436032 Chemical Structure

BAY-1436032

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18989CAS No. ：1803274-65-8Purity：98%
chem_1Get Quotation Now
 Tel: 0086-13026320035   or   orders@biochempartner.com
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
  • Chemical Properties&Biological Activity
CAS No. 1803274-65-8 Cat. No. BCP18989
Name BAY-1436032
Synonyms BAY 1436032;BAY1436032;
SMILES
Chemical Name
Formula C26H30F3N3O3 M. Wt 489.53
Purity 98% Storage Store at 4-8°C
Description BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displayed potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. In line with the proposed mode of action, a concentration-dependent lowering of 2-HG was observed in vitro accompanied by differentiation and maturation of mIDH1 tumor cells. Furthermore, BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro.
  • Quality Control&Technical Support
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.

Recommend Products

More >

Tags:BAY-1436032 supplier,BAY-1436032 purchase,BAY-1436032 manufacturer,BAY-1436032 distributor,BAY-1436032 cost,BAY-1436032 buy,BAY-1436032 for sale

0086-13720134139