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PRI-724 Chemical Structure

PRI-724

Cat. No. :BCP02465CAS No. :847591-62-2Purity:98%
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Synonyms PRI724; PRI 724; ICG001 isomer; ICG-001 isomer; ICG 001 isomer
CAS Number 847591-62-2
Purity 98%
M. Wt 548.63
Formula C33H32N4O4
Storage Store at 4-8°C
PRI-724, an isomer or enantiomer of ICG-001, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. Note: ICG-001 and PRR-724 are not the same molecule, which are enantiomer isomers. Many vendors confused them.

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