Kevetrin hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 66592-89-0 | Cat. No. | BCP16345 |
| Name | Kevetrin hydrochloride | ||
| Synonyms | 4-Isothioureidobutyronitrile hydrochloride;Thioureidobutyronitrile hydrochloride;Thioureido butyronitrile hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C5H10ClN3S | M. Wt | 179.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area. | ||
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