Belumosudil mesylate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2109704-99-4 | Cat. No. | BCP41838 |
| Name | Belumosudil mesylate | ||
| Synonyms | KD025 mesylate;KD 025; KD-025; KD025; WHO11343; WHO-11343; WHO 11343; | ||
| SMILES | CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC=C3C(=N2)C=CC=C3NC4=CC5=C(C=C4)NN=C5.CS(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C27H28N6O5S | M. Wt | 548.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. | ||
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