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Y 39983 dihydrochloride Chemical Structure

Y 39983 dihydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP18325CAS No. :173897-44-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 173897-44-4 Cat. No. BCP18325
Name Y 39983 dihydrochloride
Synonyms Y-39983 2HCl;Y-39983 dihydrochloride;Y39983 dihydrochloride;Y-33075; Y 33075; Y33075;
SMILES C(C1=CC=C(C=C1)C(=O)NC2=C3C=CNC3=NC=C2)N.Cl.Cl
Chemical Name
Formula C16H18Cl2N4O M. Wt 353.25
Purity 98% Storage Store at 4-8°C
Description Y-33075 dihydrochloride is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.Y-39983, also known as Y-33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.
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