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Vismodegib Chemical Structure

Vismodegib

Cat. No. :BCP01715CAS No. :879085-55-9Purity:98%
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Synonyms GDC-0449;GDC 0449;GDC0449
CAS Number 879085-55-9
Purity 98%
M. Wt 421.31
Formula C19H14Cl2N2O3S
Storage Store at -20°C
GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 also blocks ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. GDC-0449 is a potent inhibitor of ABC transporters, ABCG2/BCRP and ABCB1/Pgp, and is a mild inhibitor of ABCC1/MRP1. In ABCG2-overexpressing HEK293 cells, GDC-0449 increase

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