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TGF beta/Smad
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TGF β/Smad

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TGFβ/Smad

Chemical Structure Cat. No. Product Name CAS No.
Chebulinic acid Chemical Structure
BCP09990 Chebulinic acid 18942-26-2
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
Halofuginone Chemical Structure
BCP07016 Halofuginone 55837-20-2
Halofuginone is a plant derivative that has been shown to inhibit Th17 differentiation, and recently tested as a potential immunosuppressant.
Halofuginone lactate Chemical Structure
BCP18878 Halofuginone lactate 82186-71-8
Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.
Halofuginone Hydrochloride Chemical Structure
BCP19375 Halofuginone Hydrochloride 1217623-74-9
Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.
Kartogenin Chemical Structure
BCP09135 Kartogenin 4727-31-5
Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A.
SIS3 Chemical Structure
BCP19304 SIS3 521984-48-5
SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.
Pirfenidone Chemical Structure
BCP04473 Pirfenidone 53179-13-8
Pirfenidone leads to a reduction of TGF-β2 mRNA levels and of the mature TGF-β2 protein due to decreased expression and direct inhibition of the TGF-β pro-protein convertase furin.
GW788388 Chemical Structure
BCP04559 GW788388 452342-67-5
GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
SB-431542 Chemical Structure
BCP01765 SB-431542 301836-41-9
SB-431542 is potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM) and its relatives ALK4 and ALK7.
LY2157299 Chemical Structure
BCP02173 LY2157299 700874-72-2
LY2157299 is a novel selective small molecule transforming growth factor beta receptor (TGF-βR) kinase inhibitor with IC50 of 86 nM and 2 nM for TβR1 and 2 nM, respectively.
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